I did it reciently. all you gotta do is swap all your external parts (power steering, A/C, intake,Alt brackets Etc) and your good (also The 5.3L flywheel fits the 6.0). You have two types of 6.0's The LQ4 and the LQ9. The LQ4 is usually in the Silverado SS and the LQ9 is in the EXT. The LQ9 has a higher horsepower # up front outta the box and also the LQ9 has Coated pistons so you can push more outta her without fear of grenading her. Also if your goin to do it look into a GT2-3 cam and yellow LS6 valve springs and Comp cams pushrods (if you go into Lingerfelters website its all a kit) It's gonna run you about 500$ but in the long run it's worth it. If your serious about this endeavor. P.M me and I'll call you and walk you through it as best as I can. (that's how I did it)
ALSO:: Before you go into this undertaking I highly recomend reading these books first then decide if this is for you. (in the order as posted so you will know if this is for you before buying the next) #7
http://www.amazon.co.uk/Engine-Management-Performance-How-S/dp/1932494421/ref=pd_bxgy_b_img_b/279-3423632-2252931
http://www.amazon.co.uk/Modify-Management-Systems-Motorbooks-Workshop/dp/0760315825
How about the crank trigger? Will the 5.3 trigger work on the 6.0? Also, what about the balancer? I'm looking at a 6.0 crate motor that may not have the balancer included, so I would either have to use the 5.3 balancer on it, or get one specifically for the 6.0. Can I use mine?