Obvious answer is the circuit is for a windshield washer system that should come standard on a 2007 AV, as far as I know that was not an option. What was an option on some LTZ AVs is a windshield washer fluid heater system that was recalled.
According to info in the resources section page 563 or so... on this site space 21 is not used. Space 22 says rear washer though so not sure what that is for? My guess is it's a fuse block that was used in the AV and Suburbans and many Suburbans had rear wipers and possibly washers too.
https://www.chevyavalanchefanclub.com/assets/files/resources/model-years/owner-manuals/2007-chevy-avalanche-owners-manual.pdf