I haven't run my Av on a dyno but I'm guessing through my tweaks I'm push 300 HP. The 5.3 Vortec seems to be VERY sensitive to a loss of backpressure and how that impacts torque. For example an owner of an '04 Av now has 295 HP out of the box, a 10 HP gain, but that 10 HP gain came at a price, a 10 pound loss of torque from 340 to 330. For me, however I went with brute force for off-roading and load carrying, I'd rather have the torque than the HP. If I'm hung up in 4-Lo somewhere it's the torque (and some meaty tires) that's going to get me out, not HP. Further to this point the SSR puts gets 300 HP out of the 5.3 Vortec, but it came at an even bigger price producing only 310 pound feet of torque - a 30 pound drop to gain 15 HP over an '02!
With that said if you tweak the exhaust with something conservative so you don't reduce the back pressure too much. The HPP III or Diablo is going to help you tweak up the engine and squeeze out some more juice. Finally changing the intake and going with a K&N will add a few more. I think if you do these three changes TOGETHER you'll achieve your number.
Will you notice any difference? If you don't get a Diablo or HPP III to change the shift points and firmness, you won't notice a thing except your engine makes a really awesome amount of noise when you stand on it. If you spend the money and reprogram the computer, especially the shifting points then you will notice some more under the foot - however it's subjective.
Do I have regrets? Nah! The exhaust sounds so much better than stock and I definitely have a surprising amount of juice off the line for a 6K pound truck. Could have spent my money in better places, Av related or not - sure could.
Good luck on your quest and let us know what you decide!